While Led Zeppelin has endured a powerful legacy among classic rockers, one sharp criticism of the band is their unfortunate penchant for stealing songs. So much so, in fact, that we wrote an in-depth feature with a track by track analysis to determine the extent of the problem.However, one song gave us pause in the article: “Stairway To Heaven.” Easily the band’s most iconic song, “Stairway” came under fire when the band Spirit accused them of ripping it off from their 1968 original, “Taurus.” Led Zeppelin IV, featuring “Stairway,” was released in 1971.Currently, the plagiarism case is in the courts, and guitarist Jimmy Page recently made something a definitive statement on the matter. As The Hollywood Reporter shares, Page denied ever hearing the “Taurus” song until 2014.“I had not previously seen it in my collection and do not know how or when it got there,” states Page. “It may well have been left by a guest. I doubt it was there for long, since I never noticed it before. But, again, I know I did not hear Taurus until 2014.”The band’s main argument can be read here: “The similarity between ‘Taurus’ and ‘Stairway’ is limited to a descending chromatic scale of pitches resulting from ‘broken’ chords or arpeggios and which is so common in music it is called a minor line cliché… There is no substantial similarity in the works’ structures, which are markedly different. Neither is there any harmonic or melodic similarity beyond the unprotected descending line. Rather, straining to find something, the plaintiff’s expert argues that ‘Stairway’ and recordings of ‘Taurus’ have only five of the six chords in a centuries-old work — part of public domain material is still public domain material — and that both have the unprotected sequence of notes in a minor scale, A, B and C.”Meanwhile, Spirit is arguing that they performed with Led Zeppelin on a number of occasions, thus providing ample time for the band to morph “Taurus” into “Stairway To Heaven.”You can listen to both songs and compare for yourself, below:
Two groups of Harvard Stem Cell Institute researchers have independently made similar discoveries about the characteristics of induced pluripotent stem cells (iPSCs), but they have reached somewhat different conclusions about the implications of the findings.Groups lead by CONTACT _Con-379F41B299 Konrad Hochedlinger at Massachusetts General Hospital and George Daley at Children’s Hospital Boston have each found that iPSCs retain some of the genetic characteristics — an epigenetic “memory” — of the cells from which they are derived.The Daley group’s study was published online today by Nature, while the study from Hochedlinger’s group was published online by Nature Biotechnology.Daley, a professor in Harvard’s inter-School Department of Stem Cell and Regenerative Biology (SCRB), concludes that “Stem cells generated by somatic cell nuclear transfer [SCNT] are, on average, closer to bona fide embryonic stem cells than are iPS cells. This has an important political message — we still need to study the mechanisms by which nuclear transfer reprograms cells, because the process seems to work more efficiently and faithfully. Learning the secrets of nuclear transfer may help us make better iPS cells.” (To date, nuclear transfer has not been done successfully in humans.)Daley’s co-senior author, Andrew Feinberg, director of the Center for Epigenetics at Johns Hopkins University School of Medicine, says, “We found the iPS cells were not as completely reprogrammed as the nuclear transfer stem cells. Namely, DNA methylation [the natural process that ‘tells’ the cells to remember what they are supposed to be] was incompletely reset in iPS cells compared to nuclear transfer stem cells. Further, the residual epigenetic marks in the iPS cells helped to explain the lineage restriction, by leaving an epigenetic memory of the tissue of origin after reprogramming.“This paper opens our eyes to the restricted lineage of iPS cells,” said Feinberg. “The lineage restriction by tissue of origin is both a blessing and a curse. You might want lineage restriction in some cases, but you may also have to do more work to make the iPS cells more totally pluripotent [able to be reprogrammed into any cell type].”Kitai Kim, PhD, a postdoctoral fellow in the Daley lab and first author on the paper, tested mice iPS cells head-to-head with an older type of pluripotent cell made through somatic cell nuclear transfer. Best known as the cloning method that created the sheep Dolly fourteen years ago, nuclear transfer reprograms an adult cell by transferring its nucleus into an unfertilized egg cell, or oocyte, whose nucleus has been removed. The process of transferring the nucleus immediately reprograms it epigenetically, replicating the same process that happens to sperm upon fertilization, Kim said.Hochedlinger, an SCRB associate professor, says that his group, like Daley’s, found residual “memory” in iPS cells. However, Hochedlinger’s group also found that when the iPS cells are cultured multiple times eventually the genetic “memory” of their origin fades, and after about 10 passages — or splitting the cell culture into smaller populations, allowing those populations to grow, and then repeating the process — it is erased.“How faithfully iPSCs can be reprogrammed into a truly embryonic state has been a longstanding question, and we have found that the cell of origin does affect the capacity of iPSCs to differentiate in vitro into particular cell types,” says Hochedlinger. But when cultured iPSCs go through many rounds of cell division, they lose that memory, he says.“Completely reprogramming cells appears to be a gradual process that continues beyond the iPSC stage, which may explain many of the reported differences between iPSCs and embryonic stem cells,” says Hochedlinger. “The propensity of early-passage iPSCs to regenerate specific cell types could have clinical advantages, but there also are implications for the use of iPSCs to model diseases, since we’ll need to make sure that differences between cells derived from patients and from healthy controls really reflect a disease process and not this cell-of-origin memory.”Daley notes that epigenetic memory may be helpful for some applications, such as generating blood cells from iPS cells originally derived from a person’s own blood. However, continued the Howard Hughes Medical Institute investigator, the memory may interfere with efforts to engineer other tissues for treatment in diseases such as Parkinson’s or diabetes, as well as interfere with using the cells to study the same disease processes in laboratory dishes and to test drugs for potential treatments and toxicities.“These findings cut across all clinical applications people are pursuing and whatever disease they are modeling,” said Daley. “Our data provide a deeper understanding of the iPS platform. Everyone working with these cells has to think about the tissues of origin and how that affects reprogramming.”Hochedlinger’s work was supported by the Howard Hughes Medical Institute (HHMI), the National Institutes of Health, the Burroughs-Wellcome Fund and HSCI.The Daley group received support from HHMI; National Institute of Diabetes and Digestive and Kidney Diseases; the National Heart, Lung, and Blood Institute (American Recovery and Reinvestment Act); the Thomas and Stacey Siebel Foundation; Special Fellow Career Development award/Leukemia and Lymphoma Society; and the California Institute for Regenerative Medicine.— Sue McGreevey of Massachusetts GeneralHospital and Carol Morton of Children’s Hospital Boston both contributed tothis report.
Siruh Du Lac may attempt to gain compensation in Newbury’s Ladbrokes Trophy after his early Paddy Power Gold Cup exit.The seven-year-old failed to complete for the third race in succession when he parted company with Tom Scudamore at the first fence in Saturday’s Grade Three handicap at Cheltenham, on his stable debut for David Pipe.- Advertisement – “He is in the Ladbrokes Trophy and he might go there, or we might just wait and go back to Cheltenham in December for the Caspian Caviar Gold Cup.” Assessing future plans, Pipe is considering stepping Siruh Du Lac up to three and a quarter miles for the first time on November 28, in a race for which he is a general 20-1 shot.Pipe said: “It was over very quickly in the Paddy Power on Saturday – and there were a few expletives, that’s safe to say!“That’s racing, though, these things happen and he seemed fine after the race.- Advertisement – – Advertisement –
SPVG, the €375m pension fund for glass manufacturers in the Netherlands, has said it will liquidate itself and join PGB, the €16.3bn industry-wide pension fund for the Dutch graphics, packaging and process industry. The pension fund is still waiting for the DNB – the pensions regulator – to pay damages for lost returns after the watchdog forced SPVG to offload its gold holdings.The pension fund filed an €11m claim for compensation against the DNB after the regulator was adjudged to have wrongly ordered the scheme to slash its gold allocation from 13% to 3%.The pension fund’s decision to pursue compensation followed the rejection of the DNB’s appeal against the verdict of the Rotterdam court. The court had ruled that the watchdog’s reasoning in the case had been “unacceptable”.Although the DNB has not yet paid, SPVG has already factored in the €9.5m into its assets.Meanwhile, SPVG’s employer, O-I Netherlands, is to provide an additional contribution of €4m to facilitate the transfer of pension rights, which is to take effect on 1 October.Last year, the company contributed an additional €7.5m to limit a necessary rights discount of 6.1% to 4.6% for the more than 3,000 predominantly older participants.The pension fund said its employer had made the newest additional contribution conditional to a merger with PGB, which is expected to implement the pension arrangements against much lower costs.Last year, SPVG lost 11.2% on its investments as a consequence of the effect of increasing interest rates on its large fixed income allocation.
The La Liga giants have been linked with a move for the Cameroonian international, with Bayern Munich rumoured to be chasing Marc Ter Stegen. Ajax have placed a €40M price tag on Barcelona target Andre Onana, according to reports in the Daily Telegraph this weekend.Advertisement Any potential movement is likely to be based on a chain reaction caused by Manuel Neuer unwillingness to sign a new contract at the Bavarian club.Hans Dieter-Flick could then replace the 34-year old World Cup winner with Ter Stegen, leaving a space at the Camp Nou.However, Quique Setien’s side are not the only European powerhouse monitoring Onana, with Chelsea and PSG also tracking the 24-year old.Read Also: Chelsea star breaks ups four-year romance after texts to ex-pole dancerOnana came through the Barcelona youth ranks as a teenager, after joining from the Samuel Eto’o youth academy in 2010.He left for Ajax in 2015, without making a first team appearance under Luis Enrique, and has since established himself as first choice keeper for the Eredivisie side in the last four seasons.FacebookTwitterWhatsAppEmail分享 Loading… Promoted ContentWhich Country Is The Most Romantic In The World?Top 10 TV Friends Who Used To Be EnemiesA Hurricane Can Be As Powerful As 10 Atomic Bombs20 Amazing Facts About The Daenerys Of The House Of Targaryen6 Ridiculous Health Myths That Are Actually True9 Facts You Should Know Before Getting A TattooCan Playing Too Many Video Games Hurt Your Body?What Happens To Your Brain When You Play Too Much Video Games?Who Is The Most Powerful Woman On Earth?Most Popular Movies With Sylvester StalloneBest & Worst Celebrity Endorsed Games Ever Made10 Stunning Asian Actresses No Man Can Resist